REST

Learn more about REST and connect with other Simons Searchlight families with the resources below.

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Support Resources

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Research Article Summaries

Below, we have summarized research articles about changes in the REST gene. We hope you find this information helpful.

The information available about REST is limited, and families and doctors share a critical need for more information. As we learn more from children who have a change in this gene, we expect this list of resources and information to grow.

Lu et al. (2014) found that the REST gene plays an important role in maintaining healthy neurons. The product of the gene functions to protect the brain from different processes related to aging (ie: oxidative stress).

This gene also interacts with the DYRK1A gene, which has been identified in several children with features of autism.

Full versions of published research articles can be found on PubMed. PubMed is a National Institutes of Health (NIH) online database that is free. It has a collection of both medical and scientific research articles. A PubMed search for REST articles can be found here.

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Research Opportunities

Simons Searchlight

Help the Simons Searchlight team learn more about REST genetic changes by taking part in our research. You can learn more about the project and sign up here.

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Family Stories

We do not currently have any stories from REST families.

Click here to share your family’s story!