NRXN2

Below is a summary for the NRXN2 gene observed in research publications. This is not meant to take the place of medical advice.

What is NRXN2-related syndrome?

NRXN2-related syndrome most often happens when there are changes in the NRXN2 gene. These changes can keep the gene from working as it should.

Key Role

The NRXN2 gene plays an important role in brain cell function and in communication between brain cells.

Symptoms

Because the NRXN2 gene is important for the brain, some people may have:

Autism
Language delay

Do people who have NRXN2-related syndrome look different?

People who have NRXN2-related syndrome do not look different.

How many people have NRXN2-related syndrome?

NRXN2-related syndrome is very rare, and the number of people who have it is unknown.

Support Resources

Simons Searchlight Community – NRXN2 Facebook group

GeneReviews

GeneReviews are a great resource to bring to your child’s clinicians. These publications provide a summary of current research on genetic conditions and information on ongoing care.

There is currently no GeneReviews for NRXN2.

Research Article Summaries

We currently do not have any article summaries for NRXN2, but we add resources to our website as they become available.

The information available about NRXN2 is limited, and families and doctors share a critical need for more information. As we learn more from children who have this gene change, we expect our list of resources and information to grow.

Full versions of published research articles can be found on PubMed. PubMed is a National Institutes of Health (NIH) online database that is free. It has a collection of both medical and scientific research articles. A PubMed search for NRXN2 articles can be found here.

You can also visit the Simons Foundation’s SFARI Gene website to see information for researchers about this gene.

Research Opportunities

Simons Searchlight

Help the Simons Searchlight team learn more about NRXN2 genetic changes by taking part in our research. You can learn more about the project and sign up here.

Family Stories

We do not currently have any stories from NRXN2 families.

Click here to share your family’s story!