Below is a summary for the NLGN3 gene observed in research publications. This is not meant to take the place of medical advice.

What is NLGN3-related syndrome?

NLGN3-related syndrome most often happens when there are changes in the NLGN3 gene. These changes can keep the gene from working as it should.

The NLGN3 gene is located on the X chromosome, one of the sex chromosomes, and males usually have the condition. Only 1 out of 4 people with the condition are female.

Key Role

The NLGN3 gene plays an important role in the interactions between brain cells.


Because the NLGN3 gene is important for the brain, some people may have:

  • Autism
  • Seizures
  • Schizophrenia

Do people who have NLGN3-related syndrome look different?

People who have NLGN3-related syndrome do not look different.

How many people have NLGN3-related syndrome?

As of 2022, about 39 people in the world with NLGN3-related syndrome have been described in medical research.


Support Resources



GeneReviews are a great resource to bring to your child’s clinicians. These publications provide a summary of current research on genetic conditions and information on ongoing care.

There is currently no GeneReviews for NLGN3.


Research Article Summaries

We currently do not have any article summaries for NLGN3, but we add resources to our website as they become available.

The information available about NLGN3 is limited, and families and doctors share a critical need for more information. As we learn more from children who have this gene change, we expect our list of resources and information to grow.

Full versions of published research articles can be found on PubMed. PubMed is a National Institutes of Health (NIH) online database that is free. It has a collection of both medical and scientific research articles. A PubMed search for NLGN3 articles can be found here.

You can also visit the Simons Foundation’s SFARI Gene website to see information for researchers about this gene.


Research Opportunities

Simons Searchlight

Help the Simons Searchlight  team learn more about NLGN3 genetic changes by taking part in our research. You can learn more about the project and sign up here.


Family Stories

We do not currently have any stories from NLGN3 families.

Click here to share your family’s story!