De novo gene disruptions in children on the autistic spectrum< /strong> < /h2>

Original research article by E.M. Iossifov et al. < /em> (2012) . < /p>

Read the abstract here< /a> . < /p>

In this study, 343 families from the Simons Foundation< /span> â € ™s Simons Simplex Collection, who have at least one child with a diagnosis of autism, were tested with whole-exome sequencing. This study identified 350-400 new candidate genes that may be related to the features of autism, including  MED13L. A change that is believed to cause the gene to not work correctly was identified in one person and was not inherited from either parent (de novo) . < /p>

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