Excess of rare novel loss-of-function variants in synaptic genes in schizophrenia and autism spectrum disorders< /strong> < /h2>

Original research article by E.M. Kenny et al. < /em> (2014) < /p>

Read the article here< /a> . < /p>

Over 400 people with schizophrenia (SZ) and autism spectrum disorder (ASD) were screened for gene changes in 215 possible risk genes. A change in   GRIN2B   < /em>was identified to be de novo (not inherited from either parent) in a sample from a person with autism. Based on this result and previously reported cases, it is suggested that gene changes in   GRIN2B   < /em>can increase the chance for autism and can contribute to brain function and learning differences. < /p>