Learn more about the DDX3X gene and connect with other Simons Searchlight families with the resources below:


Support Resources


Research Article Summaries

Below, we have summarized research articles about changes in the DDX3X gene. We hope you find this information helpful.

The information available about DDX3X is limited, and families and doctors share a critical need for more information. As we learn more from children who have a change in this gene, we expect this list of resources and information to grow.

You can also visit the Simons Foundation’s SFARI Gene website to see information for researchers about this gene.


Mutations in DDX3X are a common cause of unexplained intellectual disability with gender-specific effects on Wnt signaling

Original research article by L. Snijders Blok et al. (2015).

Read the abstract here and the Simons Searchlight summary here.




Research Opportunities

Simons Searchlight

Help the Simons Searchlight team learn more about DDX3X genetic changes by joining research! You can learn more about the project and sign up here.


Family Stories

Stories from DDX3X families:

Click here to share your family’s story!