Below is a summary for the NLGN4X gene observed in research publications. This is not meant to take the place of medical advice.

What is NLGN4X-related Syndrome?

NLGN4X-related syndrome happens when there are changes to the NLGN4X gene. These changes can keep the gene from working as it should. The NLGN4X gene is also called NLGN4.

Key Role

The NLGN4X gene plays a key role in communication between brain cells.


Because the NLGN4X gene is important in the development and function of brain cells, many people who have NLGN4X-related syndrome have:

  • Autism
  • Intellectual disability
  • Developmental delay

Do people who have NLGN4X-related syndrome look different?

People who have NLGN4X-related syndrome do not look different.


Support Resources


Research Article Summaries

We currently do not have any articles summaries for NLGN4X, but we periodically add resources to our website as they become available.

As we learn more from children who have these gene changes, we expect this list of resources and information to grow.

Full versions of published research articles can be found on PubMed. PubMed is a National Institutes of Health (NIH) online database that is free. It has a collection of both medical and scientific research articles. A PubMed search for NLGN4X articles can be found here.

You can also visit SFARI’s website to see information written for researchers about this gene. SFARIgene: NLGN4X


Research Opportunities

Simons Searchlight

Help the Simons Searchlight team learn more about NLGN4X genetic changes by joining research! You can learn more about the project and sign up here.


Family Stories

We do not currently have any stories from NLGN4X families.

Click here to share your family’s story!